Generally speaking, Ren'py, as I prefer VNs, and that's what Ren'Py does well. I actively dislike RPGM and QSP, even though I play a fair amount of RPGM for some more niche genres (due to a lack of options). HTML, Unity, Unreal can all be good, but I'm under the impression that they're often not executed well, or development takes a long time due to the engines being a bit more complex (not applicable to HTML, except for the few devs delving into Snowman for Twine).