RPGs where you can't walk faster or VNs where there's no auto button so you have to click....awkwardly sometimes......
...and with your non dominant hand so..... lemme stop talking now.
I don't even bother with a game if it has a censored tag.
I'm also dislike futa, female prog, or bestiality.
Also outside of a small amount of games most RPGM I find lacking.
NTR = instant skip
Other than that: futa, censored, unity (hate them), game being too grindy (but it's not a tag I guess).
Also, I usually don't play games that have some exclusive content in it, feels like a waste of time since I'm missing stuff anyway
"simulator" games where you need to visit the same gym 35 times to get a scene, or ones where the story moves too quickly (i have more patience for slower progression than faster). Pacing is important.
Games that have vtal missable content without any warning or notice that it even exists and you only find out when you beat the game and the gallery is only 1/4 filled.