The artists style matters the most to me, both in 3DCG and hand drawn.
To make an example, you can have two artists which have similar art quality but only one of them uses shapes that you like, faces, lighting, angles and many other things.
Personally I like hand drawn 2d style more, but this is more difficult for many content creators to do, instead of 3d where you can more quickly pose and export a rendered image.
The DAZ games with realistic bodies and faces are something else. Completely different experience, it just hooks you up and immerses you into it as the brain can recognize the human body and face proportions. Although there are tons of stuff which is more on the cartoonish side which just slaps but in a different way.
I'm partial to 2D personally, not like I dislike 3D, heck some really good games are 3D, but 2D usually carries a specific charm that is extremely hard to resist personally. I think it's to do with how it feels like the artist put a fair bit of effort and passion into making it as good as they could which I really appreciate
I like hand-drawn. DAZ is good but many characters look alike or unrealistic. It's kind of the difference between a well-drawn comic and a poor CGI movie.
What absolutely is a no for me is the manga/koikatsu look, and whatever Insexual Awakening 2 is using.
Both work great when done right. I've seen lots of stiffly posed DAZ models that just ruin the immersion, small details like the position of hands and fingers can make or break the image.