Once upon a time I would have said Taffy Tales was up there. Still a great game, but they have taking to combining hand-drawn with AI. Not against it, just not purely hand-drawn any more.
I would say Akabur still takes the cake on hand-drawn for me. The next few months should hopefully see the release of Queen Trainer, and I think that will be lovely.
The ones I've played are Breeding Family, Milf's Plaza and A Town Uncovered and they're pretty good. I'm going to try Zombie's Retreat next, folks here say it's a pretty good game.