Scat and Sandbox. Now sometimes sandbox games are okay. There are a few where the sandbox is just you doing a bit of exploration which is fine by me. Just hate having to grind like in FOTM or Jens Dilemma. ATM Adventures has some scat but you can turn it off so its good by me.
Tags are so deceptive sometimes I don't rule out anything honestly. There's a bunch of good games with one or two often avoidable unappealing scenes that get them the tags so relying on them can cause missing some amazing games. Usually the art is a better indicator if I'm going to want to play something or not
There's no tag that's an absolute deal breaker for me, since it might just end up a small part of an otherwise good game.
That being said, I avoid games tagged with NTR, femdom or scat.