Or do you just want to have all the girls to yourself? Will you let them play with each other only when they are with you? Since some devs add this type of content. Would you have a passive trans girl in your Harem? (if you are into them)
Definition of lesbian: Girl-coded person who prefers sex or romance with other girl-coded people
Definition of transgirl: Semi-coded (has a dick or post-pubescent and doesn't have breasts) or fully-coded (doesn't have a dick and post-pubescent does have breasts) as a girl
Definition of bisexual: Girl-coded or guy-coded person who prefers sex with people who are fully coded as girls or guys
Definition of pansexual: Person who prefers sex with anyone
I like having lesbians in my harem or in their own harem, and I don't mind the MC sharing fully-coded girls with semi-coded girls. I also don't care if the girls are bisexual or pansexual, though I usually have a policy that important characters have exclusivity clauses (e.g. a fully-coded guy MC won't share an important fully-coded girl with other fully-coded guys (because guys aren't in the MC's harem), an important semi-coded girl won't share an important fully-coded girl with any fully-coded guys or semi-coded girls that aren't in her harem, an important transgirls won't share her transgirl or cisgirl partners with anyone who isn't in their relationship circle, an important transgirl NPC only will have sex with one specific other NPC).
Not every NPC has an exclusive harem, circle, or clause for a specific other NPC, but most of the time I have rules like that. The harems and circles might have overlap. It helps me to remember important characters and theri relationships if I don't play the game for a while, instead of trying to remember every single NPC's relationships. Plus I like some exclusivity in general even if there are sometimes moments where the NPCs will break the exclusivity rules.