I don't know many of the parodies, so I don't have such high expectations for them. If I am familiar with the parody, then I expect more similarity to the original. In any case, the game should be interesting, no matter how close it is to the original.
In fact, when I play, I don't listen to sounds. Although at least some background music is better than deathly silence. If there are no sounds at all in the game, I turn on something of my own.
If it's a futa girl having fun with a girl, I can try. Of course, provided that the penis is normal size, and not the size of a man's thigh. And, of course, with a nice visual.
If I like the game visually, I usually give it a chance to interest me. Depending on my mood and the phase of the moon, I can like many games. As for the safety of downloaded games, I just found a site where the admin knows how to check, and I download from there. So far I have not caught a...
I mostly play finished games. Some of them are quite long and depending on my mood I can stretch out the playthrough for a week or more. I don't remember anything specifically, but when I continue playing it pops up in my memory.
If you mean a real best friend who will always help and whom you want to help yourself, then yes. If it is your "best" friend who steals your girlfriend (NTR), then no.
I think a good story should go hand in hand with good gameplay. If I had to choose one, I would choose gameplay. A good story is needed in VNs, but I don't really like them, I'd rather read a book instead.