This is a difficult question. As many have said a parody of something SPECIFIC tends to be hit or miss. Also, the developer will need to be VERY careful with all parts of any parody. The characters, setting, situations, etc. NEED to be believable and FIT the chosen subject that is being parodied.
Of course there is also the option of a GENERAL parody. Thinking about it I would say that a VERY fun game that fits this would be 'Midlife Crisis'. I mean instead of a YOUNG(ish) MC we get a middle-aged guy. Instead of just being a pervert that only thinks about having LOTS of SEX, he is lovable, fun, funny (the guy sings GREAT songs) that actually cares about more than just banging the ladies. The games works as both a (SEXY) fun game, AND as a parody of Adut games in general.
In the end I would have to say that a parody CAN work but the Developer(s) need to be careful, work within a LIMITED universe AND accept that they will (mostly) have a limited audience.
Just a thought.