The logistics of playing some of the more complex games can surely be demanding.
But at least you know it. The worst is when you suddenly need a second hand for that one special action because the dev just couldn't be bothered triggering that one action with the mouse like 95% of the rest of the controls.
I have a razer naga trinity and use the circle number side plate custom mapping for WASD keys and map and inventory, comes in handy with games like: The last Barbarian, Sunbay, Fuckerman, Monolith Bay, Monster Girl Island
I've been there, often finding myself in situations where this was the only way to play, and it's interesting to see how some games accommodate this style more than others.