If you just want to create art images for a VN or for personal use i would say Daz3d but if you want to create thing's like original game assets made from nothing sculpting etc or animation than go with Blender just be aware Blender has a much higher learning curve
Depends on what you want from the software Daz3d has thousands of pre made products poses clothes hair etc which means you can set up things quite fast but Daz3d is a resource VRAM intensive programme especially with many newer assets that have 4k textures Daz is also rather terrible with...
There are a ton of products each is useful for different things here is a list i have used
Download them from Render-State for free
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Hope These help just a bunch i have added to my Youtube playlist over the years
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Mostly i prefer 3D but when 2D is done well it tends to be better because 2D is only limited by imagination time and skill of the artist unlike 3D Daz3d being the most commonly used programme is a bitch to use for animation