Paradise Found. I would consider the 2 sisters the main love interest due to how extensive their storyline is, but I like the neighbor and the therapist way more.
The only parody games that are good the ones where the parody isn't really the best part of it. Even the Rick and Morty one has really good animations and art for a 2D game. But it can be a nice way to get into it, like the The Library Story, i don't think I would've wasted my time with the...
I don't care that much about art remakes for most of the games. If I played it already it means the art was good enough. But a rework from a random engine to Renpy, all for it.
And for the love of god, please not another remake of Big Brother.
From what I understand, the Dev is really big in Brazil. The game is finished already in Portuguese, and he's re-releasing all of his games in english now.
the kind of game you want to make would fit in more in RAGS than Renpy. While it's cool in concept, it won't do much without proper NLP and it's hard to see that implemented in a random renpy game.
I'd just rather watch movies at home in the comfort of my living room. There's enough content around that I don't feel the need to go see every new movie.
a big +1 from me for Desert Stalker, such a good game with an excellent and fresh story.
Remember some more that work as sandbox games: the LOP games, even if they might lack in depth, the sandbox grind is not bad.
The Anomalous Dr. Vibes could also be considered a sandbox.