Depends on the story. If I feel like missing out on a significant portion of the game, then I don't like it. Since I mostly play with walktrough mods anyway, this usually does not come up though.
Oh i remember that one! Clicked through the game only to be not able to prevent the blonde (?) one from destroying the protagonist's ass with a 10 inch schlong.
Depends on the game honestly. You can make 3D animations look good, but there is a slim margin for error. If you miss, then the movement feels robotic and/or static. With 2D this is usually not the case, as most of the stuff has to be drawn first to be animated.