They can be done really well if the gameplay leans into the RPG mechanics and has some complexity. It's usually awful though.
MGQ Paradox has implemented RPG maker well.
I have pretty low interest in what are basically cute girls with cat ears, or horns. I'm looking for games where the monster girls look or act pretty monstrous.
Good examples are SHRIFT, MGQ, Domination Quest, and maybe Monster Girl Dreams. Does anyone else have suggestions?