The stories of "Company X laid off half its staff to replace them with AI then had to beg them to come back after everything totally went south" are already pretty common, and we are just getting started.
Worse yet, the constant complaining can take an emotional toll on devs and in some cases push them to abandon projects. I've seen it happen. Things are bad enough for devs now, we don't need to be making it worse.
I'd go with sister, and I don't even have to feel weird about it because I never had a sister IRL. To be honest, I'll accept any relationship in a VN because if I don't I feel bad, even though they are all just imaginary characters. If it's a relationship that doesn't interest me, I'll just fast...
An art prof once told me that it takes two people to make a great piece of art: One to create it, and one to strangle the artist when it's perfect so he doesn't keep going and ruin it. Now, I'm not advocating literally strangling this dev or any other, just saying that as projects go on and on...
"He also had a conscience." But not a very good one, because all he does is use a VR filter so he can't see his sister in pain and crying, but of course she still is.
Scurvy at least is easy to avoid since you know what causes it, as long as you lived in an area that would let you grow the right food. Now, black plague on the other hand...